Opisthorchis sinensis


 Chinese liver fluke




Physiology and Structure

  • Its lifecycle involves 2 intermediate hosts.
  • It differs from other fluke cycles.
  • Its hosts would mainly be freshwater fish. 
  • Upon consumption, flukes develop first in the duodenum and migrate to the bile ducts where they become adults.
  • They are able to live in the binary tract for up to 50 years and produce approximately 2000 eggs per day.


Life cycle






Clinical Syndromes

  • Infection in humans is usually mild and asymptomatic.
  • Severe infection with many flukes in the bile duct would lead to fever, diarrhea, epigastric pain, hepatomegaly, anorexia and occasionally jaundice.
  • Biliary obstruction, chronic infection may occur.


Treatment, Prevention and Control

  • Prevention of infection is done by not consuming uncooked fish, having proper sanitation and the proper disposal of feces.